Editorial Type: CLINICAL RESEARCH
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Online Publication Date: 23 Sept 2025

Efficacy of In-office Bleaching Gel One Week After Mixing: A Randomized Clinical Trial

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Article Category: Research Article
Page Range: 358 – 368
DOI: 10.2341/24-115-C
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SUMMARY

Objective:

This randomized clinical trial aimed to evaluate the efficacy, risk and intensity of tooth sensitivity (TS) and gingival irritation (GI), and esthetic self-perception of in-office dental bleaching using a bleaching gel 1 week after mixing.

Methods and Materials:

Forty subjects underwent in-office bleaching with 40% hydrogen peroxide (Opalescence Boost PF, Ultradent). In a splitmouth design, each maxillary hemiarch received bleaching gel that was mixed during, or 1 week before, the treatment session. The bleaching procedure was performed in two sessions of 40 minutes with a 7-day interval. Tooth color was assessed before treatment, and 1 week, 2 weeks, and 1 month after the end of bleaching, using a digital spectrophotometer (Vita Easyshade; ΔEab, ΔE00, and ΔWID) and subjective scales (Vita Classical and Vita Bleachedguide; ΔSGU). The risk and intensity of TS and GI were recorded using a Visual Analogue Scale (0-10). Esthetic self-perception was assessed using the Orofacial Esthetic Scale (0-10).

Results:

Satisfactory bleaching was achieved in both groups, with no significant differences for objective (ΔEab, ΔE00, and ΔWID; p>0.72) or subjective (ΔSGU [shade guide units], p>0.84) color assessments. No significant differences were found in the risk and intensity of TS (p=0.79; p=0.67) or GI (p=1.0; p=0.85). Patients’ esthetic self-perceptions changed after the procedure (p<0.009), mainly on the tooth color question (p<0.001).

Conclusion:

In-office dental bleaching with Opalescence Boost PF 40% remained effective, without differences in risk and intensity of TS and GI, even 1 week after mixing.

Copyright: 2025
Figure 1.
Figure 1.

CONSORT flow diagram of study design.


Contributor Notes

*Corresponding author: Avenida Carlos Cavalcanti, 4748, Block M, Office 4, Parina, Brazil, 84030-900; e-mail: aloguercio@hotmail.com.
Accepted: 24 May 2025
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